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Intermittent fasting: benefits, risks and what trials show

  • The short answer first, then the detail.
  • 7 sources, each linked in full.
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A woman smiles over a mid-morning breakfast of poha and tea on her balcony

India has fasted for a very long time. Ekadashi, Navratri, Karva Chauth, the Ramzan roza and the Monday vrat many grandmothers kept were part of ordinary life long before anyone called it intermittent fasting. The new version came through podcasts and gym WhatsApp groups, and it came with bigger promises.

Intermittent fasting means limiting when you eat, such as a 16-hour overnight gap or two very light days a week. In year-long trials it helped people lose about as much weight as cutting calories every day. It suits some routines well, and it can cost muscle if protein and strength work are neglected.

What counts as intermittent fasting?

Most of what gets called intermittent fasting falls into one of three patterns. The commonest is time-restricted eating, where the day's food fits inside a window. Sixteen hours off and eight hours on is the famous 16:8, though 14:10 is gentler and plenty of people start there. The 5:2 plan keeps five ordinary days and two days of five or six hundred calories. Alternate-day fasting swaps a normal day with a very light one, every other day, which very few people keep up for long.

Rafael de Cabo and Mark Mattson's review in the New England Journal of Medicine explains why scientists got excited. After a long enough gap, often twelve hours or more, the body runs low on stored glucose and leans on fat, making ketones as it goes. Cells also switch on clean-up and repair processes. Much of that evidence comes from mice and rats, though. The human trials, which are smaller and messier, are where you find out whether any of it changes your waist.

Sources: [1]

Does fasting work better than simply eating less?

The best answer so far comes from Guangzhou. Deying Liu's team gave 139 adults with obesity the same daily calorie target for a full year. Half of them also had to eat only between eight in the morning and four in the afternoon. At twelve months the window group had lost about 8 kg and the others about 6 kg, and that gap was small enough to be chance. Body fat, waist and blood sugar moved about the same in both groups.

John Trepanowski's trial in Chicago tested alternate-day fasting against ordinary daily calorie cutting, also for a year. Weight loss came out much the same. The striking number was the dropout rate, which was highest in the fasting group, because a day of near-starvation every other day is hard to live with. Read together, the two trials say fasting works when it makes you eat less, and about as well as any other way of eating less.

Sources: [2], [3]

What did the TREAT trial find about 16:8?

Dylan Lowe's TREAT trial in San Francisco asked a narrower question. What happens if people simply eat between noon and eight at night, with no other diet advice at all? After twelve weeks the fasting group had lost slightly more than the group eating three meals a day, by less than a kilo, and the difference did not reach statistical significance.

The detail that worried the researchers was in the body scans. In the subgroup who had them, a large share of what the fasting group lost was lean mass, and lean mass includes muscle. Picture a cousin who skips breakfast, eats a heavy lunch and a late dinner, and never lifts anything heavier than his phone. He may well get lighter on 16:8. Some of what he loses will be muscle, and that is the tissue he most needs as he gets older.

Sources: [4]

Does it matter what time of day you eat?

Possibly, and the hint points earlier in the day. Elizabeth Sutton ran a tightly controlled study in men with prediabetes, where every meal was cooked and served by the research team. For five weeks they ate all their food in six hours, finishing by three in the afternoon. Their insulin sensitivity and blood pressure improved even though their weight stayed the same.

It was eight men, so treat it as a lead worth following rather than a rule. It does sit uneasily with how many Indian households eat. Dinner often lands at nine or ten, after a long evening of tea and namkeen, and it is the biggest meal of the day. Moving the main meal to lunch and keeping dinner small and early captures some of the same idea without a stopwatch, and it is an easy experiment to run for a month.

Sources: [5]

How do you try 16:8 in an Indian home?

Start with a 12-hour gap, dinner by eight and breakfast at eight, which most people already manage. After a week, push breakfast to ten. If that feels fine, try noon. Water, black coffee and plain tea are allowed in the gap. A cup of chai with milk and two spoons of sugar is roughly 90 calories, so it ends the fast. Plenty of people quietly keep the morning chai and simply start their window earlier.

Make the first meal a real one. A late brunch of moong dal chilla with paneer stuffing, or two eggs with a roti, a bowl of curd and some sabzi will carry most people to the evening. Heather Leidy's review of meal studies found that meals with more protein leave people fuller and lead them to eat less later. That matters more when you are eating twice instead of three or four times. The second meal can be dal, vegetables and one or two rotis, finished a couple of hours before bed.

Sources: [6]

Why do some people find fasting easier than dieting?

Because one rule can be easier than fifty small decisions. "Kitchen closes after dinner" quietly removes the 11 pm biscuits, the second helping in front of the cricket and the bowl of mixture after a long day. Counting calories asks for judgement at every meal. A window asks for it once, and the rest of the day you can stop thinking about food.

It also suits some days better than others. A software engineer who is never hungry before eleven, works through the morning and eats properly at one and eight is already close to 16:8 without trying. A nurse on rotating shifts, or a mother whose meals happen whenever the toddler sleeps, may find a fixed window close to impossible. Look honestly at the shape of your own day before deciding which method to pick.

What should go into the eating window?

The same food you would eat on any sensible plan, in fewer sittings. Each meal wants a proper protein portion, half a plate of vegetables, and a modest serving of rice, roti or millet. Breaking a sixteen-hour fast with two samosas and a cold drink wastes the effort, and the sugar dip that follows usually sends you back for more.

The window is also not a licence to eat without limits. In the Guangzhou trial, both groups lost weight because their total food came down, and the clock added little on top of that. If your two meals slowly grow until they hold everything three meals used to, the scale will tell you. Weigh yourself once a week, same day and same time, and judge the method on that rather than on how virtuous the fasting feels.

Sources: [2]

Who should not try intermittent fasting?

Some people should leave it alone. During pregnancy and breastfeeding the body needs a steady supply, and long gaps are a bad idea. Teenagers are still growing. Anyone who has lived with anorexia, bulimia or binge eating may find that a rule about not eating feeds the old pattern. People taking treatment that lowers blood sugar can drop dangerously low during a long gap, so they should only fast with their doctor adjusting the plan.

For everyone else, watch how your body responds over the first few weeks. Constant thoughts about food, a binge the moment the window opens, broken sleep, headaches that never quite go, or periods that start arriving late are all reasons to stop. A good eating pattern should make your week simpler. If 16:8 is making it harder, three ordinary meals with a modest calorie cut will probably serve you just as well.

How do you fast without losing muscle?

Eat enough protein in the window and give your muscles work to do. Elisabetta Cava's review of weight loss and muscle found that the two things which protect lean tissue are adequate protein and resistance exercise. On two meals a day, each meal has to carry roughly half the day's protein. For a vegetarian that means a big katori of dal plus paneer, curd, tofu or soya, not a token spoonful of dal with three rotis.

Two or three strength sessions a week are enough to tell the body to keep its muscle. They can happen at a gym, or at home with a resistance band, a pair of dumbbells and a chair for step-ups and squats. Training shortly before the first meal of the day works well for many people, because the protein lands when the muscle is ready for it.

This is also where fasting meets what we do. Metaboliq is a doctor-led weight programme, and the aim we set with members is "Lose up to 20% of your body weight — and keep your muscle". Results vary; your doctor decides what is right for you. The muscle part of that sentence is why protein and strength work matter more than the length of the fast. The first step is a home blood test that a doctor reads, so a fasting plan is set with your sugar and thyroid in view.

Sources: [7], [6]

So is intermittent fasting worth trying?

If a shorter eating day fits your routine and quietly ends the late-night snacking, it is a perfectly reasonable tool. Give it a fair trial of a month, keep the protein up, keep lifting, and weigh yourself weekly. If it leaves you starving, short-tempered and raiding the kitchen at noon, go back to three meals and cut a little from each. The year-long trials suggest you will lose about the same either way.

Religious fasts deserve a separate word. A Navratri day of sabudana khichdi, aloo and fried kuttu puris can easily hold more calories than an ordinary day. Ekadashi with fruit and milk is lighter. If you already fast for faith, there is no need to change that. Just know that its effect on weight depends on what is eaten when the fast opens.

Sources: [2]

Every source, in full

Linked to the publisher or to the abstract, so you can read them yourself.

  1. [1] de Cabo R, Mattson MP. Effects of Intermittent Fasting on Health, Aging, and Disease

    The New England Journal of Medicine, 2019. Reviews the metabolic switch from glucose to fat and ketones during fasting and the evidence, much of it from animal studies, on intermittent fasting and health.

    Read the source
  2. [2] Liu D, et al. Calorie Restriction with or without Time-Restricted Eating in Weight Loss

    The New England Journal of Medicine, 2022. Over twelve months, adults with obesity on the same calorie target lost similar weight and body fat whether or not they also limited eating to an eight-hour window.

    Read the source
  3. [3] Trepanowski JF, et al. Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial

    JAMA Internal Medicine, 2017. Alternate-day fasting did not produce greater weight loss or maintenance than daily calorie restriction over a year, and dropout was higher in the fasting group.

    Read the source
  4. [4] Lowe DA, et al. Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity: The TREAT Randomized Clinical Trial

    JAMA Internal Medicine, 2020. Eating within an eight-hour window without other advice produced only a small weight difference from three meals a day, and much of the loss measured in a subgroup was lean mass.

    Read the source
  5. [5] Sutton EF, et al. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

    Cell Metabolism, 2018. In a small controlled feeding trial, eating within an early six-hour window improved insulin sensitivity and blood pressure in men with prediabetes without a change in weight.

    Read the source
  6. [6] Leidy HJ, et al. The role of protein in weight loss and maintenance

    American Journal of Clinical Nutrition, 2015. Reviews the evidence that higher-protein meals increase reported fullness and reduce later intake compared with meals matched for energy but lower in protein.

    Read the source
  7. [7] Cava E, et al. Preserving Healthy Muscle during Weight Loss

    Advances in Nutrition, 2017. Reviews why weight loss removes muscle as well as fat and the evidence that adequate protein and resistance exercise help preserve it.

    Read the source

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